It most likely will. I had soo much trouble playing through the dlcs in Fallout 3. If you can "get" it for the PC. It runs much smoother..
I played F3 just on the PC when it originally came out and didn't get any DLC (was new to me then). When I saw the F3 GOTY edition with that huge hardback guide I plowed through it with joyful abandon as it was alot more stable for me. I got it first for the 360 till the disc got scratched (round and deep) then I got the PS3 version and have never looked back.
The PC is much easier to fix with using console commands and mods by the excellent fan based community. Problem is with four kids and only one PC plus a laptop that can't run 3D games it was just easier for me to switch to a console. I abandon the xbox360 (now its just for my kids cause of Halo) as I got tired of my discs getting these weird circular scratches (lost Bioshock 2 and others because of that issue) and the PS3 is alot more media friendly for my rips of music and videos (BluRay discs hold up better imo) and I don't have to pay a subscription fee to play any online games.
I am not anti steam or anything but the anti piracy measures make running PC games a pain for me. I don't want to create an account just so I can play a game and give out more of my private info to the man. Not to mention having to constantly shell out for more up to date hardware to run things. I just miss the days of buying a PC game, popping it in, enter the serial key, and getting down to business. But i have been computing since the Commodore 64 days and even though it seems things are better now, I just get tired of having to do detailed research to resolve issues with mods and the like. Plus moving a console around is much simpler for me as I am a cripple (I like that word for some reason).
One thing going for this issue is there is a ton of documentation and its not one console specific so patching is much more likely; just not necessarily promptly resolved, but there is still a bunch I can do in the Mojave wasteland and maybe someone around here will figure out a workaround eventually.