I try so hard not to, but there's something unavoidably hilarious about being a low-level character and throwing a fireball at one, regretting it as soon as it starts shooting poison back, running around working out how on earth to kill it when you can't reach it with a sword, and then the leg-flappy animation when it finally dies...
...I probably need help.
Haha, I did that exact thing in Ald-Ruhn once XD Good times.
But I do sometimes. My current character's an alchemist, so if I feel I can take something, I'll always kill it for the ingredients.