The ending in Van Buren has you in a nuclear armed space station along with the guys who you've been alternately chasing and running from. The 8 nukes in the station are aimed at Shady Sands, New Reno, Vault City, Hoover Dam, New Canaan/Jericho, Brotherhood Main Headquarters and Maxson Bunker. Also known as the largest and most succesfull cities in the wasteland, so it's a pretty big deal. You only have 2 hours to stop the launch while fighting off or reasoning with the bad guys. But no matter what you do, 2 missiles are gonna launch, but luckily you can reaim them at 2 cities you've visited and built into thriving civilizations or destroyed over the course of the game, posing a moral conundrum.
But then I thought, what if you could save all the cities you've helped, and still have a challenging moral dilemma? You could reaim the missiles back at the space station, and yourself. This would spare all the cities of nuclear death, but to make you actually think if you don't sacrafice your self you can play after the end. And it has to be a awesome, post-game play to make it even harder, all new dialogue, the cities change drastically, maybe even all new quests. The player would either have to give all that up, or if they've been Mr. Goodytwoshoes sacrafice themselves.
So what do you guy's think?
If not, then I reccomend aiming at Burham Springs. It's only populated by three not particularly friendly guys, and dozens of terrifiying Hell Monsters. Even solving all the quests it's just a very small town.