I found The Superhuman Gambit to bit a bit silly. I didn't really enjoy this one at all, it just didn't fit in with the Fallout 3 theme and seemed a bit pointless. :huh:
I remember someone saying how they completed that quest quick-smart, without having to chase after one or the other. I did that in this play through as I never want to do that quest as it's just silly.
Basically as they are yelling at each other I wandered up and lobbed a couple of grenades at the ant side, killing the Antagonizer almost straight away before she could run off. The other guy took off, I didn't chase him.
Uncle Roe was most surprised and happy that I'd fixed their problem so fast. He has dialogue for that, which is different, so I didn't screw anything up.
Tranquility Lane is another that I try and put off for as long as possible, when I start a game from the Vault, which is rare now. Even though I can be in and out within minutes.