I would like to start by saying I've played all the Fallout games, from the first PC games to Fallout 3 on Xbox 360 and this New Vegas one now on PS3, and I loved them all. However this latest one may be my last as the continual crashing is starting to get the better of me. The problem I'm suffering seems to be related to transitioning from one area to another, either while walking along when the game pauses, presumably to load area data, or while waiting for the game to load after entering a door, along with a few crashes while attempting to save the game.
I haven't experienced save game corruption, and touch wood I hope I never will, but I have read others have had their game progress halted as a result due to it.
Fallout 3 on the 360 had a few crash related problems, and from what I recall they were of the same transition related nature, but nowhere near as many as this New Vegas release. It seems rather than address the problems of Fallout 3 they have exasperated them.
Bethesda, please listen to your flock, when they say there appear to be serious crashing problems, it just may be true.