Let me get this straight.. you want to take away, what was already watered down: Character freedom..
Fallout is about being a freeform character that is why in all other games you can decide your age, build, six etc.
It is also the reason why there is no character interaction prior to the start of the game. Bethesda has used this mechanic themselves for nearly every TES title. You start as a blank sheet.. So you the player can create/ roleplay the character that they want.
FO3 abandoned this technique by giving you a full blown backstory, and though bland it sets down a few things you can never roleplay:
Amata is your friend, Butch bullies you etc. etc..
Adding romance within that framework especially if it is gender specific would take away even more freedom for character development.
The non Bethesda title you use are different in many aspects. Unlike older RPG's like FO or the way how Bethesda frames their protagonists, bioware often chooses a specific role/character for you... and let's you develop that character..
Romance in a freeroam game can work.. but should be limited to logical characters (ie followers) and should be completely optional and able to be influenced by player choice.
(It is telling that Fable II had more depth in marriage than Skyrim.. incl. sixual preference, dialogue, romancing etc...)
Personally I would like them (whoever is going to make it) to leave it out..