Nobody really cares about mixing races. Reman had Khajiit lovers and nobody cared, so did Barenziah and nobody cared (about the race anyway). One of the Emperors married a Dunmer and the only reason people cared was because she came from Morrowind. They would have cared the same if Morrowind was inhabited by Bretons. The only people that really seem to care are the Dunmer and the Altmer, for the rest from what we've seen it's irrelevant.
I'm sure Ulfric Stormcloak and the many Nords that share his views would beg to differ. I'm sure the Thalmor and their views of being the 'pure' race is another example of Tamriel views. I don't think Imperials and Nords have a problem with each other as Tiber Septim was a Nord after all. I think I read that Nords do seem themselves as purer though. I'm guessing many Imperials will see Nords as barbaric and uncivilised in comparison to themselves.
When the Nords first discovered the Bretons they were going to wipe them out until they heard them speak in a language which was broken Nordic and they realised what and who they are. Bretons are still often treated as lower class citizens by many Imperials and Nords. Look at the way the Forsworn are treated in the Reach. In High Rock they have a caste system. My guess is the more man genes are at the top.