This was inspired by my watching Amazing Spider-Man and noticing the guy who played Richard Parker. Look at http://blogs.sundaymercury.net/anorak-city/SPIDER-MAN%20Richard%20and%20Mary%20Parker.jpg and tell me that he doesn't a strong 'Arcade Gannon' vibe to you (minus the wife, obviously).
Though now that I'm actually thinking about it, I don't usually associate any particular character with an actor, except when they're actually the voice actors - like John Doman for Caesar (actually a good physical fit, too) or Felicia Day as Veronica.