So here's a fairly long (two pages!), and actually pretty competent sounding preview, from PCgamer, that goes into a bit of detail about the Repcon quest (which is called "Come Fly With Me"), talks about hardcoe mode, and mentions (what sounds like it might be a major spoiler to) Boone's quest, as well as a few other things.
If you don't mind a few spoilers, it's very worth the read (

and thanks to the boys and girls at NMA for posting it): http://www.pcgamer.com/2010/10/06/chugging-down-toilet-water-in-fallout-new-vegas
Playing Fallout: New Vegas in hardcoe mode is a revelation. It feels how its already worthy predecessor was meant to. The vast amount of clutter you can sweep into your inventory starts to make sense, as much of it can be sold. Medicine and the new Survival skill suddenly become central, and the blinking lights of a Nuka-Cola machine can signal your salvation.
For existing Fallout players, it’s refreshing just to be forced into a character reboot – after 80-plus hours in Fallout 3, you could critically damage a Deathclaw with a raised eyebrow. But on top of this, the limits imposed by hardcoe mode enforce a fresh appreciation for the nutritional potential of your inventory, your health, your addictions, your tactics and your relationships with the inventories of the NPCs around you. It makes you far less blasé about the game’s systems, and makes tactical combat (and, at some points, its avoidance) a necessity rather than an occasional dalliance. The fact that your ammo now has weight means that you might become more appreciative of melee weapons, too.