I should avoid putting points into charisma? Is that what you mena by "dump"?
Also, yeah I was especially thinking of getting GN and Skilled. What about Confirmed Bachelor and Lady Killer? I've heard they help with some stuff.
Charisma is good for a pure Speaker type char, as a lot of points in it will make your companions very deadly indeed. I'm currently playing a more speech-oriented playthrough, and with a CHR of 8, Boone and ED-E pretty much blow away anything I don't kill in the opening volley of a fight. But if you plan to beef up EW's a lot, then you may not need or want such deadly companions.
The majority of the human enemies you'll meet in the game are male, so pick whichever perk applies to the six of the character you make- if male, pick Confirmed Bachelor; if female, pick Black Widow. Either of the other choices would be for flavor only, if you feel like you have a lot of perks to waste... heh.