I was wondering if its possible to get around the game's load save at death. I wanted to do a afterlife/resurrection type mod where yhe person who dies losses all his/her/it's items as well as some Karma (Karma Lost at rez) and goes to a paradise,place of torment, or limbo based on Karma level at death (And has to hunt for the resurrection portal/item in a out of the way and pain in the butt location). Not sure though to bypass the vanilla death thing of reloading last save at death..

Its most certainly possible. Arwens realism tweaks "One life module" does that very thing.
You'd just have to cater your script with all the things you want implemented after death.