Tell us all about the most infuriating part of the game where you forgot to save.

Me, I was doing Went to the Republic of Dave from Megaton, I went for Ol' Painless. I tried to pickpocket the safe key of Dave, but he caught me. Didn't feel like reloading, so I attacked him. Suddenly everyone in the town has me cornered and killed while I was reloading [~.~] and after the scene of me dying, I was standing at the gates of Megaton. I hate it when the auto save doesn't work.