You need a better set of equipment from time to time, and the game needs to give you that either directly, as loot you can use, or indirectly, as stuff you can sell in order to buy what you need. The quests that provide information, or entry to another quest are more important to me than the ones that give me an overpriced lump that I won't use, and can't sell for its marked "value". My Oblivion characters typically use equipment they've enchanted themselves, using base items bought from vendors. They need to find loot to sell as they go along, but it doesn't have to be epic, or even useful beyond its sale value (by which I mean the gold I can get by selling it, not the price on the tag). Most of my dungeon-diving is done for weapon or spell practice, and I frequently ignore the chests unless I'm running short of cash, and even then it's often easier just to make and sell a few potions.
I'd be happy if there was no "loot" in dungeons at all.