I am planning what is likely one of my most complex house mods ever, and well one thing I want to do is create an event that removes the long travel from one area to another afterwards

think long stair well, character goes up/down the first time and maybe the second time. But from then on doesn't have to worry about the stairwell cell, as the door at the entrance now pops down to the door at the end of the stairs bypassing them. (so there is not long travel time to use the house)

Or am I going to need to disable/enable doors in the same location for this to work.



note: I do all my mods without script extenders (not everyone uses them) with as much vanilla content as possible.

Your other proposed variant (enable/disable) should be the way to go here.
In oblivion, OBSE had a function SetDoorTeleport, but FOSE doesn't.

+1

Your going to have to use the multiple-door enable/disable thing - which will achieve the same exact effect your looking for.