I'm pretty much at my wits end here. I've tried employing the .dll fix, the Stutter Remover, and the 4GB fix. Nothing works. I'm running a fairly modern system with a very good video card, capable of running New Vegas at Ultra settings with no discernible slowdown (at least when I first start the game...)
In terms of mods, I have Project Nevada, Fellout, and Interior Lighting. I have a few mods that add more detail and buildings to certain areas of the game, as well as some quest mods. If you need a precise list, I'll provide one, but if anyone can suggest a fix or knows the nature of the issue I'm having, I'd really appreciate it! Thanks!