http://fallout.wikia.com/wiki/Pauline_Wins
"There is no Karma or reputation loss for killing both of them and taking their hats, but
they do not drop a key to the safe when they die. The PC must either pass the Speech check of 55 or pick the very hard lock that requires 100 in Lockpick if they wish to open the safe and retrieve http://fallout.wikia.com/wiki/Vance%27s_9mm_submachine_gun."