Many of us here will agree that the Elder Scrolls has vast and original lore, which is often poorly capitalised upon by Bethesda's writing staff. With a back-locker of lore comparable in size perhaps even to LoTR, it seems a shame that we get handed shoddily written characters - serving only to move the player from objective to objective - or outhright joke characters which seem so ridiculous that it shatters immersion.
This is why I think the "big focus" for the next Elder Scrolls game should be STORY. Bethesda need to look at the state of the TES universe, and create a convincing and intriguing plot, not one wherein you are "prophesied hero X, fated to do/save/slay Y". While I can see that many gamers desire only combat,you've created an engaging combat system for Skyrim (perhaps a bit dumbed down) which will satiate their appitites. The focus now needs to be on story. With the sales of well written games like Mass Effect (no ending discussion please), Deus Ex and even the Witcher skyrocketting - the gaming Market clearly has the appetite for a good plot to enjoy their game with. To avoid falling behind Bethesda, you need to address the writing situation, and even hire new writers with experience beyond games (movie writers with a passion for games). The universe is there, but you need to do it justice with plot.
Thoughts, anyone?