Just wondering if there is any way for the Enclave Remnants to make a comeback (and win) that doesn't involve gigantic plot holes or bad writing? I know the Enclave are basically either all dead or really old but the Remnants in NV can still put up a pretty good fight. And by comeback I don't mean "hey guys lets go to D.C and take over" but just a small town or something kind of like Navarro.

I actually would like them to be less on scope but not dead.. I am assuming that they will centralize their efforts in less risky places..

Yeah that's kind of what I was thinking maybe like an old secluded army base or bunker but not like the scale they were in Fallout 3 that made no sense at all.

Remnants of the Enclave who have given up in the idea of nation wide (global genocide) of anyone not Enclave... Could find an ally in a like minded faction.

Such a faction I can think of would possibly (if Bethesda makes it canon) the Midwestern Brotherhood under General Barnaky.

Under Barnaky the MWBoS actively kills all mutants and those that side with them. Since we learned the Enclave have/had an outpost in Chicago in Fallout New Vegas and we know the MWBoS is in Chicago as well given that it is their back yard and mentioned in Fallout 3. And it was hinted in FoNV that the MWBoS are also still in Colorado. So this would mean the MWBoS is a faction that still has locations across the Midwestern United States.

The way I see it, the Enclave on their way to DC set up their outposts in Chicago as a relay. There they encounter the MWBoS. The MWBoS greatly out number the Enclave but have an advantage in tech. The MWBoS make a deal with the Enclave. We let you pass through our lands freely, if you share your tech and knowledge with us. The Enclave have made deals in the past with wastelanders if it suits their needs. So they make a deal, leave some people behind at the outpost which they were going to do anyways.

After Fallout 3 the remnants from DC regroup in Chicago. Knowing their only chance left at regaining any real power is to work with the MWBoS. They don't breed with them or anything like that, but they agree to be the MWBoS' tech guys in exchange for protection, a buncher and supplies. The MWBoS let Enclave join and become elders and the remnant's influece could then grow.

Not saying I would want that, but I can see it as a possibility.

Since it talks about the Enclave outposts in Chicago it would make since they would go there. Maybe all the Enclave that didn't want to kill all the mutants (just kill supermutants, and maybe ghouls) relocated there. If I remember correctly Colonel Autumn was like that it was Eden that was hardcoe anti mutant. And since there was the option of letting Autumn live maybe we'll see him in the future?