I'm running a GTX 590 at 1680x1050 with 1xSMAA, all settings and textures at very high EXCEPT for particles (medium), shaders (high), and shadows (high), and my FPS drops to 25-27 on the first level of the game (when you get the bow for the first time, looking out onto that stormy deck). I was expecting my FPS to stay around 45 fps, but dropping down that low seems absolutely ludicrous.
I realize that my card isn't exactly the Geforce Titan but nevertheless it's a really high end card (performance just above that of a 680) So I'm not really sure what to think right now - Is the game running normally or is it a performance issue, SLI scaling issue, etc?
EDIT: CPU: i7 2600k, hyperthreading off, overclocked to 4.4
RAM: 8Gb Ripjaws