Had an idea that I'd like to implement - see title. I was thinking that by using a AI Package such as Flee or Travel, flagged as Run to a xmarker that is hovering in thin air, also stretching out some navmesh over a mountain edge that I could make a NPC jump to its death or land in water. Anybody tried this, would the NPC do the "leap of faith"?

I have played mods where NPCs have done this, so it is possible. The only one I can think of off hand is for Fallout 3, the Underground Hideout quest.

To get the best Wile E Coyote effect where the NPC goes out for a little way before falling down, give them some of the Whirlwind Sprint effect before they run to that point.

Just also bear in mind that NPCs can't actually jump. So as CCNA mentioned some kind of Whirlwind Sprint effect will be required.