Basically, at least 2-3 times per match, using Grendel+Rapid Fire 3, clicking the mouse button to shoot will not do anything but only once. It's like the mouse click was not even processed in the game, or perhaps I pressed the button when the delay was still in effect, though I imagine that there is some kind of queue that would prevent this.
I would really like for someone to investigate it, however it may be hard to reproduce unless you are actually facing an enemy.