I have been having this issue with Skyrim for quite awhile now. I don't think it has anything to do with any mods that I have installed. Sometimes it looks as if I am looking through a kaleidoscope when playing Skyrim and it's quite annoying. I am running the "High Res Texture Packs" everything is pretty much maxed out except shadow which I have on medium. The game has the current patch. Drivers are current. I run the game at 1920x1080 on one monitor not dual. Most of the time I get 60 FPS but every once in a while I will get a temp drop in FPS when I am leaving from the inside of a building to the Skyrim world or when I am in some town because I use the "Towns and Villages Enhanced" Mod but I've gotten this issue even with that mod unistalled, so I know it is't that mod.
Here are my specs for my computer (I built this machine a few years ago and I can't imagine this is caused by any hardware issues such as my GPU's but I'll post specs anyways.
Monitor: Samsung S27A550H 27" x2 (Dual Monitors) MB: ASUS P8P67 Deluxe B3
CPU: Intel i7 2600k 3.4GHz (OC'd @ 4.4GHz) & Corsair Hydro H60 CPU Cooler HD: Crucial C300 128GB SSD (C Drive) & WD Caviar 1TB 7200RPM x 2 (Storage) GPU: EVGA 460GTX 1GB SC EE X2 SLI RAM: Corsair Vengeance 16GB DDR3 1648MHz & PSU: Corsair 850HX
Here are 3 pictures too help show you what I am talking about.
http://s24.postimg.org/c9rqz32vp/photo_1.jpg
http://s24.postimg.org/78kcxpvf9/photo_2.jpg
http://s24.postimg.org/6x2wkyez9/photo_3.jpg