Often after a fight my quick keys don't work any more and i can't use any dialog options on Meeko, i don't know if it is a vanilla issue or mod related...but i hope some one know what to do because this is starting to get annoying. The only way to get the keys to work again is to save and reload the save, but that ruins the immersion totally when you have to do it almost after every fight

Sounds like a conflicting mod.

Definitely related to a mod issue, I will move this so you can post your load order.

Skyrim.esm
Update.esm
Dawnguard.esm
HearthFires.esm
Dragonborn.esm
Skyrim Project Optimization.esm
SPIKE.esm
Unofficial Skyrim Patch.esp
Unofficial Dawnguard Patch.esp
Unofficial Hearthfire Patch.esp
Unofficial Dragonborn Patch.esp
SkyUI.esp
iHUD.esp
SKSE Hotkeys.esp
Clock and Save key.esp
StaticMeshImprovement.esp
Better Dynamic Snow.esp
TheSkyforge.esp
Gildergreen Regrown.esp
Supreme Fog.esp
Realistic Light.esp
Environment.esp
ShadowFix.esp
Wilderness of Skyrim.esp
Point The Way.esp
Merchants.esp
Morthal Trader.esp
Destroy the Thieves Guild.esp
Lights Out Quest.esp
The Choice Is Yours.esp
ArchmageTolfdir.esp
Paarthurnax.esp
No Quest Items.esp
HorseCompanions.esp
Convenient Horses.esp
DogCompanions.esp
SetNewHome.esp
FollowerRelax.esp
Housecarls.esp
NPC Makeover.esp
Run For Your Lives.esp
WerewolfMastery.esp
Headtracking.esp
Realistic Ragdoll & Force.esp
Dynamic TimeScale.esp
Dual Wield.esp
Thalmor Elven Armor.esp
Painful Traps.esp
Locational Damage.esp
Skyrim Speeds.esp
UnreadBooksGlow.esp
SleepingWear.esp
CampingGear.esp
IngestibleItems.esp
Backpack.esp
My Journal.esp
Bandages.esp
Containers.esp
Portable Crafting Kits.esp
Prolonged Poisons.esp
Smithing.esp
Racial Powers.esp
GameFix.esp
MyFix.esp
MYFixDB.esp
Open Face Helmets.esp
Guard Dialogue.esp
Sit Anywhere.esp
Alternate Start - Live Another Life.esp