Hello community

i have a problem i despretly need help with my skyrim copy has been running fine ever since i got my new toshiba laptop and then just a week and a half ago i downloaded 200 mods was working fine as long as i had only 100 activated then the next day no music thought it was my saves deleated them then no affect then i deleted every single mod no affect uninstalled and reinstalled skyrim twice no affect updated my drivers both audio and video no affect then i defragged my external hard drive the drive that skyrim is on no affect i dont know what else to do please help and currently the only mods i have is all five unoficial patches and the high resolution dlcs as well as the three add on packes only things active please help i beg of you community i am out of ideas