Is there a way to make an invincibility mod like an Invincibility spell and also an Invincibility enchantment?

you can make a perk that makes you invincible, then make a spell/enchantment that applies that perk.

How do I setup that perk for to become Invincible care to explain or I can youtube it?

Never been a fan of youtube for learning creation kit.

http://www.creationkit.com/Perk_Entry_Point

You'll want to use the mod incoming damage entry point.

Not sure off the top of my head if that affects destruction spells.