Although my experince with Fallout New Vegas has not been as "bumpy" as some others (I have frozen just a couple of time), I do have an anoying bug:
When I installed the silencer on the weathered 10mm pistol I get two issues when arming and using the gun:
(1) The screen gets a white tint where you can't see very well, and
(2) the gun is invisible when in your hand so that you only get an empty fist and the aiming reticle.
Wierdly enough, you can see the gun for an instant when you load new amo into it.
PS: I also get NPC's sleeping in the air beside the bed.
Aside from that, great game. I love it.