Well, after getting the Skyrim: Legendary Edition, I'm starting to see some changes in Marie Motierre. In short, after adopting two children and spending some time with her spouse in Whiterun, she suddenly turned into a werewolf and massacred Whiterun and Riverwood. Then she attempted to build a house near Pinewatch, failed, and now has a small, humble abode near Dawnstar, all by herself. She has effectively abandoned Whiterun and her family. Needless to say, I did not plan for this to happen, it just happened and I went on with it.
So, did any of your characters ever take a path you least expected? For good or worse? Share your stories!