I'm not sure if this is a mod issue, or if its a technical issue with the game or my PC. But no other game does this.

Anyways, when I started a new playthrough I quicksaved in Helgen Keep and my PC froze, I couldn't alt+f4 and I couldn't ctrl+alt+del out of it so I had to reboot my PC by holding down the power button. Every thing was fine after that but I wasn't able to load the save where I froze, I had to load an older save to keep playing.

Then today the same thing happened when I quicksaved just outside Ivarstead, this time I let my PC run, but I clicked ctrl+alt+del, after a while the ctrl+alt+del screen showed up and I just exited back out of it and the game was working again. But I restarted the game because the glitch where the windows mouse cursor shows up happened. It worked fine after that, but when I went back to my house in Whiterun the same thing happened again, I did ctrl+alt+del and after a while the ctrl+alt+del screen showed up and every thing worked again.

The only change with this save file is that its a clean save, it has the same mods as my other saves except this is the first new game after I installed SKSE and SkyUI. I'm on SkyUI 4.0 right now but the first time it froze when I was in Helgen Keep was on SkyUI 3.4.

I validated the Steam files twice but it said it needed to redownload a 752 KB file both times I validated my Steam files.

Anybody know what's going on?

Please provide your mod list load order, your specs, and give some more detail on when you think this is happening. Like does it freeze only when you save? Are you using a save game mod?

Have you made a merge patch with your mods? Are you using Nexus Mod Manager? Windows 8? etc

Edit: Here's what I wrote for Fallout 3, having done this with skyrim and other games, I get much better fps, and zero perfomance issues that I was having before. It makes your interface retro, but its worth it for me