I've always been a little disappointed in Corpus disease. There very few adverse effects to having the disease, and there's little incentive to be cured. I think it would be very cool if the disease hindered the player from equipping armor, weapons, clothes as the disease progressed. This could be accomplished by forcing the player to wear certain items in place of their armor. These items would be made to look like growths resulting from corprus disease. As the disease progresses the player would eventually become covered in these growths which would hinder the player greatly. Eventually people would become hostile towards you and guards would attack you on site. I lack the scripting and modeling know-how in order to pull this off, but I would be overjoyed if anybody here could create such a mod.