I plan to play FO3 again and completely ignore the main questline, but do my own roleplaying as soon as I get past the vault part, does anyone have any kind of archtypes, or goals I could have? I.E protecting towns or caravans, scavenging, assassinations, etc

Kill off every single fiend in Vault 3. "Leon" or "Hitman: Bloodmoney" style. Then hunt down and kill the Driver Nephi, and the rest of the leaders.

Why? Because they put down an entire vault, men women and children. And if you have ever seen what beastialiy a druggie [censored] up on LSD is able and willing to do in a drug induced haze or whilst looking for drugs, to men women and children, you will do the same. I allways clear out the Fiends in all of my playthroughs. Even the ones where I sided with the legion. There are some things I cant and wont forgive and that are too vile for me to accept. One of them is that these people should be allowed to breathe the same air I do. .

Edit: Sorry, misundestood and took this as an NV thread. My bad .

Slaver? i'm playing a slaver right now and it can be quite fun roving the wastes and enslaving anyone you can find, it also brings in decent money at 250 caps a slave. you could also be an assassin, setting yourself targets and motives and a specific way you have to complete the assassination.(Long Distance, not suspicious, Etc.)

What kind of targets? and what kind of assassin? Sniper rifles and being unseen, or pistols and getting out quickly?