Right click your SKSE icon- loader.

Go to properties,

up in left corner it says "Compatibillity" Select it,

Right below it says "Compatibillity mode"

and right under that check small box "Run this program in compatibility for:"

If you run windows 7 like me just leave it at Windows XP (Service Pack 3) or simply select your OS.

You might also need to check box for "Run this program as an administrator"

-Have fun.