Embrace of the Mantis King! with Super Slam, Piercing Strike, Slayer, Paralyzing Palm, and Ninja?

I think so. It is almost too easy in OWB with The protonic inversal axe with the Super Slam, Piecrcing Strike, and Slayer perks.

Melee and unarmed are really strong in New Vegas. I'm surprised it isn't as popular as sneak + guns.