Every time that I play this game, there are people that I can't resist killing. No matter which faction I'm aligning with or what sort of karma I'm going for, I just can't abide Fantastic, Cachino, or... every Powder Ganger being alive to see the ending credits. What about you guys? Are there people you just have to end?

Probably Barton Thorn everytime I walk past him on the way to primm I remember how he screws you over and I always kill him and the lottery winner in nipton.

kill fantastic after you get his password.

i kill holmes. that he comes to me and gives me a good reason to kill him.

Oh ya I forgot about Holmes I always kill him for his star bottlecaps yet I never do the quest.

I killed Holmes always, because the way I made it look was hilarious, I made my dialogue choices to make my character first raise an eyebrow, acting innocent like "Oh really? Wowwww..a murderer?! Oh wow, we better be careful than, thanks for the advice!" Which than as soon as he turned around, his skull fragments kissed the dusty ground and walls as my shotgun wanted to ask him a question and sadly sneezed.

I always kill Holmes too. He doesn't deserve it, I just like getting the roving trader gear.

Others who always die:

Dermont

Saint James

Jeannie May

Andy Scabb

Benny

Edit: Also Joe Cobb, Eddie and all other regular Powder Gangers.

You don't even have to wait; you can pick up the password from his corpse.

definitely Jeannie May. I also try to "ensure" that Big Sal, Nero and Cachino all take each other down in the Gomorrah quest. Karl, naturally. The Legion better keep their claws out of my Khan peeps. Caesar and Lanius usually, because I'm not nuts enough to side with the Legion and if I'm going independent I certainly don't want them as a neighbour.

And dean domino. But I always keep him sweet before I do, so he'll tell me what he did totally confidently, assuming I'm as much a piece of [censored] as him.