[Can't post links to an example] There should be a box saying E: Talk but sometimes, it doesn't appear.

So, some vendors and quest NPC's and no-name blokes alike can't be talked to. They might glitch in and out if I come back later, but some more than others. I've noticed Ysolda and Miss Blacksmith the most; also had it from 2 quest-givers inside the Bannered Mare and one outside Dawnstar. If that's any help, Ysolda hasn't glitched since we got married.

Haven't seen any other reports of this, or of similar problems - but most of all haven't found a solution. If it has to be dealt with through console, I'd be fine with that, as long as a solution exists. Found no commands to initiate dialogues in the wiki either.

I'm playing the Steam version with HF+DG+DB, on win7.

The closest I found on this forum was a problematic mod so I stripped my build bare from mods, even the unofficial patches. Tried running it from SKSE and from Steam. Nothing worked. So, any and all help appreciated !

I think maybe because the mod you have deactivated.

But your save relies on that mod now, so maybe that's the problem.

Have you tried opening the console (` key by default), clicking on the NPC in question, and typing "resetAI". That should reset the NPC's AI and hopefully unstick her.