Umm... like most of them? I may just be a hermit but...
Markarth : Too dwarven in a game with no existing dwarves, and it just is soo jumbled and the forsworn forced quest. Plus the guards their are always jerks
Morthal : Too plain and rather pointless... rarely go there.
Falkreath : Love the area around it, but typically only do the city itself if I want the Ring or Hircine or to do Clavicus Vile's quest.
Windhelm : Too prejudice.
Solitude : Too grand... until recently I hated the Imperials also, I recently have flipped a bit.
Winterhold (as a city) : Pointless
I'd say I spend about 80% my time within Whiterun hold if not the city itself. I like the accessability of merchants near the house there.
Dawnstar is alright, and Riften I end up needing quite a bit... and I kinda like it there though don't know what for.