Seems like you can't since they don't seem powerful enough to defeat mutants.

Yes. Yes you can win Fallout with small guns. The Sniper Rifle to the eyes is an awesome weapon. An even better Weapon is the Red Ryder BB Gun.

The sniper rifle is all I've been using, I just cant seem to get up close to the super mutants because they always have better weapons. So I've been building up my energy level to get a better gun. And where can you get the Red Ryder BB gun?

If you are going with small guns it would be good to have a high luck, good to great perception and high agility and take perks such as Sniper and Better Criticals. That way you don't need to get up close to the super mutants, you can stand back an snipe them, which is what the Sniper Rifle is for.

The RR Ryder BB Gun can be found in a special encounter called Bob's Used Car Mart which if you have a high or maxed out luck you will encounter. It will be locked in the building behind Bob in a locker.

Would 5 be an okay Luck? (I think I already know the answer)

If not what drugs will increase luck?

Aparently there is a guy named http://fallout.wikia.com/wiki/Chuck_(Fallout)that can increase your luck in Fallout.

Charisma is pointless, just letting you know that. So you can lower that to 1 and bump the rest into luck.

When I make a small guns guy, it is a sniper character which IMO is the only way to go. So yeah, high luck 10 would be the best. High agility and perception and take the perks that help with getting better criticals and before you know it you will be mowing down Super Mutants with single shots to their eyes.

Well I guess I can make a new character. Dang I thought I built my character perfectly, stupid luck