It will be very tough on legendary. When you transform to VL form, you lose all armor. You gain health, but with no restore spells or potions available, you'll soon realize that high level enemies will be able to hit you for a lot of your health. A couple of hits and you're dead.
I'm not trying to discourage you, I play a vampire and go into VL form on legendary with mods that make enemies more powerful. You'll just have to pick your spots and be more careful than normally. It's quite a good challenge actually. VL is actually much weaker than being normal at high levels, not more powerful. Just keep that in mind and you'll do great.