Of all pivotal, important things in this game, this is the one that remains unanswered.
Why in the hell did House effectively destroy Vault 21?
By all accounts, Vault 21 was a paradise, and this isn't exactly something you can discount as mere vault dweller nostalgia or propaganda, given that it's an extremely, EXTREMELY rare case where a vault designed as a social experiment rather than one designed to actually save lives produced exceptional results in the form of a thriving vault filled with survivors who not only came out of the vault alive, but were also exceedingly happy with their lifestyle within the vault.
So why in the hell did House fill it with cement? Why in the hell did he insist on the "destruction" (destroyed it's culture and society, but didn't physically destroy it or it's inhabitants) of the vault?
Presumably, the only reason we've ever been given for this, is because House wanted the vault dwellers as part of his regime and under his control, not out of any form of neccesity or danger they presented.
I've said before that to me, the King is House's Achilles' heel, because while I like House, I'd choose the King over House if given a choice. This? This is in a way another Achilles' heel, because this is a working society that had a new idea, a new way of thinking and a new lifestyle, and it was crushed. Why? Presumably it was crushed not even to save House's society or culture, but rather to support it. Their support was by no means neccesary, and yet he forced them on board as though it were. Hell, he took a decent risk in doing so, since he didn't have any guarentee they'd support him instead of just wandering off, and yet he STILL saw fit to destroy their entire society for that mere chance. If such a justification is truly the case, House's actions are tantamount to slavery.
But we've never been given a clear answer as to the why of it, and it's rather hard to believe; if such reasonings were true, then the seemingly logical and pragmatic House suddenly takes on a new light as obsessive, abusive and downright dangerous. So yeah, let's speculate: why in the HELL would someone fill a vault with cement?