The obvious drawbacks could be that since my cities are at least three times the largest one of vanilla that they might be 1 difficult to encircle in walls by al sides and second that they add lot of new things that might slow down perhaps on some smaller machines.
Is there a way to test performances ? I have a good pc and have no signs of slow downs but others might be less lucky.
The other issue I see is for eventually dragonriders ( I think there are some mods that allow that ) that could spy over the borders of a cit or in theory be able to overcome walls.
Finally my cities are all but flat and develop usually more vertically than vanilla so parts might be accessible from climbing mountain sides or the like ....
This is why I need to carefully plan what to do if close them or make them open.