Had a Z68 chipset MB I had to replace but since it is no longer made I upgraded to a Z75 chipset board...
At first skyrim crashed to desktop once it hit the end of the main screen(continue, load, new, option, etc). I got that resolved by resetting the sound configuration to match my soundcard(M Audio Delta 2496)...
I no longer get CTDs and can start the games, but once it passes the Bethesda logo, the sound disappears and doesn't come back in game. There also appears to be serious lag in game whenever I try to talk to someone or there are a lot of sounds, even though nothing gets heard/played.
I have tried setting it to all settings at 48,000 and 44,100 16bit and 24bit, but nothing has resolved it. I have played it with the same setups, mods and sound/video card for two years and never had this issue. Also do not have this issue on any other game, just Skyrim...
Any help? Suggestions?