I have always loved the Fallout series and I have played through all of 3 and New Vegas. I have always wanted to see a Fallout based game in the southern states of America. I feel that New Orleans would be a the perfect setting for such a game. With New Orleans being a place filled with culture, a Fallout universe twist on the Crescent City would be intriguing. Since New Orleans rests just below the sea level in several places, it would be great to have parts of the city submerged underwater, much like the Rivet City in Fallout 3. Also, some mutated native animals would be great, such as giant mosquitoes instead of bloat-flies and a morphed alligator to look similar to a mirelurk.

http://www.gamesas.com/topic/1484659-fallout-4-speculation-suggestions-and-ideas-188/h. Thanks!