Considering Lord Harkon was a bit older than 4000 years old from the SKYRIM: Dawngaurd DLC lore I imagine he is around 3000 years old in ESOs time, which means he must be alive and well in Skyrim. I hope we can do quests for him if you are a vampire, or something in that Idea range and find castle volkihar if it exists. If this is not already in the game I am hoping it will be in an expansion or future patch. Anyone with Ideas or theories is more than welcome to comment please.

This must be before he went insane. Would Serana be around at this time too?

He should be around, and since he got his power from Molag Bal and Molag Bal has a huge part in tihe story of this game it'd fit right in.

No. Because she isn't even familiar with "the empire" when you mention it to her.

Serana I feel would probably be around, although maybe not, as I some in the lore forums say she might have been imprisoned during the interegnum(the dark ages essentiallly). the interregnum by the way, would be the point in which eso takes place. Which in my opinion eso isnt portraying the feel of the interegnnum(what we knew about it that is) very well.

Source: http://www.gamesas.com/topic/1472746-when-serana-got-put-away/?hl=+serana

actually ESO would be taking place about the time Serena was born so they would still be a lord and a lady living in their castle with a newborn child at this time it would actually fit in if he had just got his powers and was just forming his army and WE were that original army of vampires, along with the werewolves just forming around this time as well

Honestly, I think this thread would easily win all future "PvE" debates.

I think she actually said "Which Empire?" That could mean the last thing she remembered was a period when there were several empires battling for control.

But, yeah, you're probably right.

Serana might be in her chamber though... She doesn't recognize the Empire of Cyrodiil at all... She even said "Cyrodiil ended up with an Empire? Wtf happened?" (Not exactly but basically that XD)...

So... This might be when Lord Harkon is, so to say, a bit insane... But he should be around for sure hiding out in his castle near Skyrim.

Serana is in the box during ESO.

Whaaat?

*Heads to Skyrim*

Wasn't the first empire founded pretty close to the beginning of reccorded histoty? Serana's statement never made much sense to me.

Serana imprisonned herself way before ESO