My problem with Wrye Flash was this, from the log:
Found Python at 'C:\Python27\python.exe' Launching Wrye Bash in debug mode Traceback (most recent call last): File "Wrye Bash Launcher.pyw", line 32, in bash.main() File "C:\Playthings\Steam\SteamApps\common\Fallout New Vegas\Mopy\bash\bash.py", line 293, in main import bosh File "C:\Playthings\Steam\SteamApps\common\Fallout New Vegas\Mopy\bash\bosh.py", line 84, in import balt File "C:\Playthings\Steam\SteamApps\common\Fallout New Vegas\Mopy\bash\balt.py", line 41, in import wx File "C:\Python27\lib\site-packages\wx-2.8-msw-unicode\wx\__init__.py", line 45, in from wx._core import * File "C:\Python27\lib\site-packages\wx-2.8-msw-unicode\wx\_core.py", line 4, in import _core_ImportError: DLL load failed: %1 is not a valid Win32 application.Tried python, wxpython, and pywin32 with both 32 bit version and 64 bit version.