So there you are, in some building tucked away, proud your perception lead you to it. You scrounge and come upon a safe, but a lockpick skill says you need 75, yet you can't do squat because you've only got 30.
Do you return later and open the safe/door or do you forget about it?
I always forget about them. You know that lock in one of the abandoned houses in Minefield? I've yet to unlock it. I've no idea what it contains, and there are many areas in the game I've never seen because I never go back to unlock doors.
I thought about this as I was clearing out the National Archives. There are two doors requiring a lockpick of 75, but I'll never go back to check them out. What would be the point? I got what I came for.
So spill it: clean up or leave it?