I almost always roll with it, even if it makes things harder for me or my PC. I make exceptions for
really awful bugs and NPC behaviors that are so stupidly unrealistic I can't rationalize it away (stupid as it may be, I don't count NPCs attacking creatures that are way out of their league among this--it has to be beyond the normal realms of AI behavior/total immersion-breaking stupid beyond the game's design). Or I'll reload if I just hit the a button at the wrong time when selling something I didn't mean to or drink a potion I didn't mean to. The occasional response lag when selecting things messes me up. Oh and, of course, dying. I am not a DID person.