The HD DLC takes over 4GB Harddrive space and 3 esp slots (not including the unofficial patch for it) which are the reasons why I never personally used it. I've watch my friend play Skyrim with it on his computer which has the same specs as mine an AMD PHENOM X4 955 Black Edition & AMD HD RADEON 6870 1GB RAM and I've noticed there were a lot of stutters here and there in his game even with the High Res DLC optimized mod from the nexus.
The only major texture and mesh improvement mod I have is Static Mesh Improvement, would it be better to get the HD DLC or opt for some mod instead like Skyrim 2k or Ultra HD textures?