You can't really go wrong with this game, it is not too unforgiven for certain obscure builds or playstyles. That said, these are some things that make it easier for new players:
- Invest some points in weapon skills on level up, before level 10 small weapons and melee/unarmed are good skills to raise
- Radroaches are easier to kill with melee than weapons most of the time
- Lockpick, science and speech are good secondary skills
- When you follow the main story the game is pretty balanced. The only difficulty I had was going into the metro tunnels for the first time
My advice is to start playing, do some sightseeing and follow the main quest at your own pace. Exploring some areas around the main quest can be pretty rewarding!