1. Main Quest - it's much better than the ones seen in Morrowind and Oblivion. (I can't compare it to Arena's and Daggerfall's main quests because I haven't finished them.)
2. Better Combat and has also Mounted Combat. Two handed weapons are wielded properly. Bashing.
3. Possibility and need to equip stuff (including spells) in one hand or another.
4. You can turn HUD off and the game is made in way it's fully viable to play it without HUD.
5. All skills affects in leveling not only the major skills like in Oblivion.