I recently started playing Skyrim again. Since I hadn't uninstalled it since the last time I stop playing, I still had all my mods. I came to the realization that I don't like the graphics mods. I dunno why, it just doesn't feel real, it feels artificial. So I removed every single mod, even the official high res DLC, because honestly, I don't care if the trees or bushes look slightly off when I stare at them from just an inch away. I unticked the high res DLC in Steam so that it won't download again.
The only mods I have now are mainly fixes like the unofficial patches, SkyUI, Skse, XP32 skeleton, realistic ragdolls. I also have bella's better females with less makeup and XCE's overhaul loaded before. I'm thinking of removing bella's better females, though, but for now I'll keep it. I will not for the time being (or ever again) install a graphics mod. No, not even the FXAA injector because the grey filter suits Skyrim so well. It's not supposed to be a colorful place like Cyrodiil.
I've never really been a fan of any graphics mods or any big overhauls that seriously hurt the FPS. So, save for the mods I currently run, I'm "usually" a vanilla kind of guy.