So I was just wondering if anyone else has issues leaving the presidential suite of the Lucky 38 after a certain point in the game? I stored all my stuff in there that I wouldn't be able to take in to any of the other casinos, to make it easier for myself, and eventually went back to pick it up. However when I went to leave the suite I wasn't able to talk to Victor or access the elevator. In the end I had to load up a older save that didn't have any of the New Vegas missions finished/started yet.....
This question leads me to think you have the exact problem I do. I played completely through the game and never used lucky 38. I stayed with Easy Pete for the whole game. This time round I decided to use 38 as I was taking more of a look around the wasteland. I started bringing stuff there that I collected before getting to the strip. One load and all was well. On the second load, when I got up to the suite I couldn't talk to Victor anymore.
I reloaded the previous where I brought the first load in and he was working. I exited the casino and came back in, no problems. I tried with and without the companions with me. No problems. So I go back and get the other stuff again and come back.. go upstairs and click on Victor and again.. nothing.
Something in the inventory is causing this. I don't know what yet, but will probably check it out by loading up smaller loads till I find out exactly what it is. Probably one of the unique armors I have collected or something like that.
Since you said you were storing stuff up there when it happened, I think we are in the same boat.